منابع مشابه
On gap junction structure
We have studied the stain distribution within rat liver gap junctions for specimens prepared by thin sectioning and negative staining. Pools of stain molecules exist in two specific locations with respect to the distinctive morphological units (connexons) of the junction. One pool of stain surrounds the connexons and is restricted to the extracellular space in the gap between the adjacent plasm...
متن کاملNonredundant gap junction functions.
The need for molecular heterogeneity of gap junction channel proteins in vivo has been enigmatic. Recently, functional replacement of one channel gene with another in mice and flies has revealed that cellular health depends not simply on gap junction communication but also requires the correct type of intercellular channel subunit.
متن کاملGap Junction Voltage Dependence
All vertebrate gap junction channels display voltage-dependent gating. Historically, voltage-dependent behaviors have been characterized as being transjunctional voltage (Vj) and membrane voltage (Vm) dependent. The transjunctional voltage dependence of gap junction channels composed of two identical hemichan-nels, each composed of identical connexins subunits (a homotypic channel) is usually s...
متن کاملConnexin trafficking and the control of gap junction assembly in mouse preimplantation embryos.
Gap junction assembly in the preimplantation mouse embryo is a temporally regulated event, beginning a few hours after the third cleavage during the morphogenetic event known as compaction. Recently, we demonstrated that both mRNA and protein corresponding to connexin43, a gap junction protein, accumulate through preimplantation development beginning at least as early as the 4-cell stage. Using...
متن کاملTrafficking of gap junction channels at a vertebrate electrical synapse in vivo.
Trafficking and turnover of transmitter receptors required to maintain and modify the strength of chemical synapses have been characterized extensively. In contrast, little is known regarding trafficking of gap junction components at electrical synapses. By combining ultrastructural and in vivo physiological analysis at identified mixed (electrical and chemical) synapses on the goldfish Mauthne...
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ژورنال
عنوان ژورنال: Reactome - a curated knowledgebase of biological pathways
سال: 2007
ISSN: 1934-1792
DOI: 10.3180/react_9411.1